Season 5 is the first season of Arc 2 - College Years. It has a total of 24 Episodes, which aired in 2013.
- Nina Dobrev as Elena Gilbert
- Zack Roerig as Matt Donovan
- Candice Accola as Caroline Forbes
- Michael Trevino as Tyler Lockwood
- Ian Somerhaulder as Damon Salvatore
- Ashley Benson as Indianna Braxdon
- Matt Dalas as Thomas Latch
- Jane Levy as Hannah Maxwell
- Hailee Steinfeld as June Flemming
- Tyler Posey as Aaron Johnson
- Lyndsy Fonseca as Emma Moon
- Mila Kunis as Jennifer Banes
- Michelle Christine Tratchenberg as Maya
- Anna Sophia Robb as Miranda Talbot
- Wes Bentley as Kreshnik
- Evanna Lynch as Jessica Pretley
- Gary Oldman as Brandon
- Freya Mavor as Rina Novak
- Cody Christan as Sean Mcconnell
- Wes Ramsey as Dakota Blake
- Ben Kingsley as Valan
- Krasen Belev as Simeon Petrova
- Sasha Johnson as Sarah Johnson
- Emily Browning as Serliah Kettle
- Ariana Grande as Cassandra Dawn
- Holland Roden as Amelia Sage
- We will see Stefan anytime soon in Season 5. Also, Stefan will not be a regular.
- Katherine will be around a lot, and is the focus of the series. She will start college.
- Elena and Damon will be reccuring roles.